I don't have Vista but I do have a MAC and I also run Windows XP on it. Wacom is compatible with everything so if something isn't supported, they will have the drivers for it in short order. Since Wacom is so popular and for good reason, it works, all the OS's make sure they have compatibility to it.
With a larger tablet if you have desktop room, you can be more comfortable. I like to just sit back and draw with the table on my lap. I have some trouble with an elbow, kind of a different repetitive injury than Carpel Tunnel, so the use of the keyboard is not as good for me, whatever the tablet can do, whatever I can use to navigate with the pen is better still. And I have the Intuos, so surfing the web and dragging my finger is nice.
Besides, it draws really nicely.
Getting something which costs more like this tablet was difficult for me to justify. But I wouldn't trade it now. I have a Graphire at home and at work and I do use the Graphire still at work. I also tried an Aiptek tablet which turned out not to be so compatible with many programs I use. Or the program would crash on account of the tablet. No good.
In the end with the Wacom, you do get what you pay for. You can search for the best price.
I also got a keyboard which is adjustable for easing my wrist and elbow problems, and some bean filled cushions to fill in the gaps. Much more comfortable. I got a Gold Touch keyboard. It is nothing like the more widely used Microsoft Natural Keyboard. My elbow was in the worst pain of my life after using that. No, this is adjustable in two axis by 30 degrees both ways, so you can get quite a tilt, and with a lever, easy to flatten it, to put your keyboard draw away. It doesn't have a numeric keypad but it has a num-lock key which allows you to use the standard keys on the right hand for a keypad or you can get an optional separate keypad. Now I can use my wide Wacom 6" x 8" on my keyboard drawer next to my keyboard so it is much more comfortable for me. It is the change of body positions which is important, and I can type comfortably with the keyboard also on my lap. It promotes a neutral wrist. It is especially bad on your writs when your hands are cocked up at the wrist. I you are used to touch typing, the time to adapt to the keyboard is minimal. I got mine on Ebay for $35.00, with shipping is was still under $50.00. I got a good deal.
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