I never thought I would have a problem with this. I paint with both hands. Sometimes I use my left and at others the right hand is more comfortable.
I change in the middle of a drawing so it is a constant change.
My new pen and touch has right or left hand orientation so the buttons stay out of the way.
My problem seems to be that I either must turn off the touch to avoid laying my hand on the tablet or change orientation every time I switch hands.
A bit of a pain but I am sure I will get used to it.