She looks quite -- well they both look quite filled with love and life. It's a great choice of photos in that regard.
As to the eyes, you have taken on a real challenge, especially owing to the angle, and the lack of reference. I don't know how well you knew her and have what her eyes looked like enough to use your memory to get it right with the help of another photo, perhaps from a different angle.
Try to find a pic that gets the angle and somewhat the lighting.
The best thing I can offer is really take advantage of the layers feature in ArtRage, where you can experiment in a very forgiving way. It will be perfectly in context as if you were painting right on the painting. But you can keep trying that way until it works, and it will match whatever level of finish you get into the rest of the painting. It's a 'see as you go' kind of thing. Get the shapes down first and then the skin tone and shadows etc.
I don't know how to do this in ArtRage (others may offer suggestions), but if you have a program that lends itself to photo manipulation, you can splice eyes from another photo onto this one like a photo retoucher might (with all the tricks that they use). And then you can use that as the original and paint from that.
Those are the only two procedures I can think of.
Challenging. But if you decide you can't quite pull it off, you can always include the glasses as they appear. I think it's a charming, warm photo.
Let us know how you do!
"Not a bit is wasted and the best is yet to come. . ." -- remembered from a dream