I use different settings for different situations (which I normally play with and test until I'm satisfied). I wouldn't recommend recording an entire drawing/painting session all in one go. It's best to stop recording and save what you have every so often. This should help keep things from lagging up on you. Once you are done, you can bring all the video clips into a program like Windows Movie Maker to compile and compress them together.
For example, if I'm doing a tutorial, I may record at higher quality setting (around 75 - 80) and drag the Max Framerate over (with the Auto Adjust checked) until the Playback Rate reaches 12, which should set the Capture Frames setting to around 83 milliseconds. But even at a lower quality and frame capture rate, the files will still be large.
When I plan to record myself actually painting/drawing (and not doing any explanations), I set the Capture Frames setting lower. But again, this depends on what type of working I'm doing. If I'm sketching, I might set the Capture Frames setting to around 1000-3000 millisecond (so, 1-3 frames per second), but if I'm doing detail work I might make it even lower, because in playback it will speed up the process of the slow going detail work, while keeping the file sizes down.
Nothing is easy to the unwilling.